Measurement of anesthetic uptake kinetics in the brain using 19F MRI and cross-correlation analysis after pulsed application |
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| Authors: | Maxim Terekhov Alexander Scholz Laura M Schreiber |
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| Affiliation: | 1. Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany
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| Abstract: | Object We present a pilot study based on 19F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain. Method The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by 19F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants. Results The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues. Conclusion The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies. |
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