Characterizing cerebral oxygen metabolism employing oxygen-17 MRI/MRS at high fields |
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Authors: | Ali Gordji-Nejad Klaus Möllenhoff Ana Maria Oros-Peusquens Deepu R. Pillai Nadim Jon Shah |
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Affiliation: | 1. Medical Imaging Physics, Institute of Neuroscience and Medicine-4, Forschungszentrum Juelich, 52425, Juelich, Germany 2. Department of Neurology, Faculty of Medicine, RWTH Aachen University, JARA, 52074, Aachen, Germany
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Abstract: | This article provides a comprehensive overview of oxygen (17O) magnetic resonance spectroscopy and imaging, including the advantages and challenges offered by the different methods developed thus far. The physiological role and relevance of oxygen, and its participation in aerobic metabolism, are addressed to emphasize the importance of the investigations and the efforts related to these developments. Furthermore, a number of methods employed in the determination of the cerebral metabolic rate of oxygen in neural cells will be presented, focusing primarily on methodologies enabling absolute quantification. |
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