Spectroscopic techniques as a diagnostic tool for early detection of osteoporosis |
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Authors: | Kanika Singh Kwang-Sung Lee Donggeun Lee Yong Ki Kim Kyung Chun Kim |
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Affiliation: | 1.School of Mechanical Engineering,Pusan National University,Busan,Korea;2.Endocrinology and Metabolism, College of Medicine,Pusan National University,Busan,Korea |
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Abstract: | Osteoporosis (OP) a kind of bone disease, is very serious in particular for old persons, and may lead them to immobility and
death. Early detection of the diseases is the first consideration for the patients to have more options to live a healthy
life. The biomarkers or bonemarkers provide a promising challenge in clinical proteomics for early disease detection. In this
paper, optical techniques such as Fourier Transform Infrared Spectroscopy (FTIR) and UV/Visible spectroscopy are employed
to find the bone markers and emphasis has been given on noninvasive modalities for early detection of osteoporosis. Blood
plasma samples procured from two groups, patients and healthy persons were tested. Both of the optical techniques revealed
obvious differences in the spectra; between two groups, for example, increase in intensity for OP persons. New peaks were
found at 1646, 1540, 1456 and 1077 cm-1 in FTIR spectra. Except 1588 cm-1, we showed decrease in spectral intensity of OP
persons. In UV/Visible spectroscopy results, new peaks appeared in the OP patients spectra at the wavelength of 279 nm and
414 nm. These differences in the spectra of the two types samples, allow rapid and cost-effective discrimination of the potential
patients with the optical techniques which were verified by the bone densitometer in the hospitals. The new and novel technique
is quick, reliable and effective. |
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