Dietary Marine-Derived Tocopherol has a Higher Biological Availability in Mice Relative to Alpha-Tocopherol |
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| Authors: | Naohiro Gotoh Hiroyuki Watanabe Tomiko Oka Daisuke Mashimo Noriko Noguchi Kazuhiko Hata Shun Wada |
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| Affiliation: | (1) Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku Tokyo, 108-8477, Japan;(2) Department of Health Science, Kochi Women’s University, 5-15, Eikokujicho, Kochi Kochi, 780-8515, Japan;(3) Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Meguro-ku Tokyo, 153-8904, Japan;(4) Nippon Suisan Kaisha, Ltd, 559-6, Kitano-machi, Hachioji Tokyo, 192-0906, Japan; |
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| Abstract: | The biologic availability of two kinds of tocomonoenols, marine-derived tocopherol (MDT) and α-tocomonoenol, was investigated
in ICR mice. Vitamin E-deficient ICR mice were fed MDT and α-tocomonoenol together with α-tocopherol, β-tocopherol, γ-tocopherol,
and δ-tocopherol, and storage in liver, spleen, lung, and brain was quantified using reverse-phase high-performance liquid
chromatography. The vitamin E relative biologic availability (VE-RBA) in liver was 100 for α-tocopherol, 26 ± 3 for β-tocopherol,
4 ± 2 for γ-tocopherol, not detected for δ-tocopherol, 49 ± 6 for MDT, and 30 ± 7 for α-tocomonoenol. The VE-RBA in brain
was 100 for α-tocopherol, 5 ± 2 for β-tocopherol, not detected for γ-tocopherol and δ-tocopherol, 8 ± 1 for MDT, and 4 ± 1
for α-tocomonoenol. Tocopherols and tocomonoenols did not accumulate in the spleen or lung. MDT and α-tocomonoenol had high
VE-RBA values. The VE-RBA value for MDT was much higher than that for β-tocopherol. |
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| Keywords: | α -Tocomonoenol Liver Marine-derived tocopherol Mouse Vitamin E relative biologic availability |
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