再生丝素/壳聚糖共混纳米纤维的结构与性能

以98%的甲酸为溶剂,不同质量分数的再生丝素溶液和3.5%的壳聚糖溶液以质量比70∶30共混静电纺丝。测定了壳聚糖的含量对共混膜的结构及力学、溶解等性能的影响。结果表明:随着壳聚糖相对含量的增加,丝素β化程度提高,纤维结晶度增大,丝素与壳聚糖以70∶30共混时的溶失率最小;甲醇处理后,溶失率明显降低;共混纳米纤维的断裂强度随着壳聚糖相对含量的增大而增加,柔软性也逐渐提高;共混纤维膜具有优异的抗菌性。

Microstructure and Property of Regenerated Silk Fibroin/chitosan Blended Nanofibers

The electrospinning of various concentrated regenerated silk fibroin(SF) solution and 3.5 % chitosan(CS) solution with the composition ratio 70∶30 was performed using 98 % formic acid as spinning solvent. The influence of chitosan's relative content on blended membrane's microstructure, mechanical property and the rate of water-dissolved was measured. The result indicated that with the relative content of chitosan increased, the β-sheet and crystallinity of SF were enhanced. When the composition ratio was 70∶30, the rate of water-dissolved was least. After 60 min treatment by methanol, the rate of water-dissolved decreased significantly. The breaking strength and pliability of blended membrane were increased gradually with the increased content of chitosan. The electrospun SF/CS membrane had excellent antibacterial property.