柿果多酚对高脂血症小鼠脂代谢的影响

目的：研究柿果多酚调节高脂血症小鼠脂代谢的作用。方法：高脂血症模型建立成功后，选取雌性昆明小鼠80只进行实验分组，以正常小鼠为对照A组和B组各10只，对高脂对照组、柿果多酚高、中、低剂量组和辛伐他汀阳性药物对照组各12只，实施各口只不同灌胃处理。测定小鼠血清总胆固醇(TC)、血清总甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂质过氧化物(LPO)、肝组织游离脂肪酸(FFA)，以及超氧化物歧化酶(SOD)、脂蛋白酯酶(LPL)、肝酯酶活性(HL)。结果：柿果多酚能显著降低高脂血症小鼠TC、TG、LDL-C、LPO、肝组织FFA(P＜0.01)，对HDL-C提高不显著，能显著提高血清SOD及肝组织LPL、HL活性(P＜0.01)。结论：柿果多酚可通过调节机体脂代谢减轻高脂血症，预防动脉硬化(AS)。

Effect of Persimmon Fruit Polyphenol on Lipid Metabolism of Hyperlipidemia Mice

Objective: To explore the effect of persimmon fruit polyphenol on lipid metabolism of hyperlipidemia mice.Methods: Totally 80 mice were divided into 7 groups including normal control group A and B,high blood fat group,persimmon fruit polyphenol groups at high,middle and low dosages and positive control group were treated with different supplementations after the hyperlipidemia mouse model had been established through high fat diet.Levels of serum total cholesterol(TC),total triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipid peroxides(LPO),hepatic free fatty acid(FFA),superoxide dismutase(SOD),lipoprotein lipase(LPL) and hepatic lipase(HL) in mice were evaluated.Results: Persimmon fruit polyphenol could remarkably reduce the levels of serum TC,TG,LDL-C,LPO and hepatic FFA(P<0.01),slightly increase the level of HDL-C and notably improve the activities of SOD,LPL and HL(P<0.01).Conclusion: Persimmon fruit polyphenol could alleviate hyperlipidemia by regulating lipid metabolism of mice,thus preventing arteriosclerosis(AS).