Characterization of Reed-Sternberg cells with granulocyte specific monoclonal antibody |
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Authors: | GM Memon SM Alam |
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Affiliation: | Department of Pathology, Jinnah Postgraduate Medical Centre, Karachi. |
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Abstract: | Monoclonal antibody Leu M1 represents a highly specific marker to locate granulocyte antigen in Reed-Sternberg cells in Hodgkin's disease. Except the L&H variants of reed-sternberg cells in lymphocyte predominance variety in which antigens are probably sialylated. All the cases of non-Hodgkin's lymphoma were negative with this marker, because of absence of antigen. Therefore this specific marker characterizes granulocyte origin of reed-sternberg cells. |
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