Induction of apoptosis in HEp-2 cells by infection with herpes simplex virus type 2 |
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| Authors: | AH Koyama H Akari A Adachi F Goshima Y Nishiyama |
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| Affiliation: | Department of Virology, School of Medicine, University of Tokushima, Japan. |
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| Abstract: | Although herpes simplex virus type 1 (HSV-1) does not induce apoptosis in infected HEp-2 cells, herpes simplex virus type 2 (HSV-2) did induce apoptosis in a small but significant fraction of the same cells. Apoptosis was not observed in Vero or HeLa cells infected with HSV-2. In addition, HSV-2 infection in the presence of cycloheximide induced extensive apoptosis of HEp-2 or HeLa cells. |
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