Norflurazon—An inhibitor of essential fatty acid desaturation in isolated liver cells |
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| Authors: | Tor-Arne Hagve Bjørn O Christophersen Peter Boger |
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| Affiliation: | 1. Institute of Clinical Biochemistry, The National Hospital, University of Oslo, Rikshospitalet, N-0027, Oslo 1, Norway
2. Univers?t Konstanz, Lehrstuhl für Physiologie und Biochemie der Pflanzen, D-7750, Konstanz, Federal Republic of Germany
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| Abstract: | Norflurazon is a herbicide known to inhibit carotene biosynthesis and linolenic acid biosynthesis in plants. In the present
work, the effect of norflurazon on the metabolism of essential fatty acids was studied in isolated rat liver cells and in
rat liver microsomes, incubated with 1-14C] labeled linolenic acid (18∶3, n−3), dihomogammalinolenic acid (20∶3, n−6) and eicosapentaenoic acid (20∶5, n−3). Norflurazon
(0.1 mM, 1.0 mM) was found to inhibit essential fatty acid desaturation. The Δ6 desaturation is inhibited more efficiently
than the Δ5 and Δ4 desaturation. The chain elongation of essential C18 fatty acids to their C20 and C22 homoglogs was not inhibited by norflurazon. |
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