| 用近红外光谱-PLS法非破坏性分析吡嗪酰胺片 |
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| 引用本文： | 滕乐生,年综潜,逯家辉,郭伟良,蒋朝军,孟庆繁.用近红外光谱-PLS法非破坏性分析吡嗪酰胺片[J].吉林大学学报(工学版),2006,36(3):443-0446. |
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| 作者姓名： | 滕乐生 年综潜 逯家辉 郭伟良 蒋朝军 孟庆繁 |
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| 作者单位： | 吉林大学生命科学学院生物药学系,长春130012 |
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| 基金项目： | 吉林省科技发展计划项目（20020503-2）. |
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| 摘 要： | 应用偏最小二乘法结合近红外光谱法(NIRS-PLS)对吡嗪酰胺片中吡嗪酰胺的含量进行了非破坏性定量分析。采用近红外一阶导数800~1200 nm光谱区间建立了吡嗪酰胺片中吡嗪酰胺的含量定量分析模型,校正集预测值与真实值的相关系数(R)达到0.9989,预测均方根误差(RMSEP)为0.563,表明所建模型准确可靠,预测准确度高,NIRS-PLS方便快捷,可作为药品分析的一种常规方法。
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| 关 键 词： | 药物化学 近红外光谱法 偏最小二乘法 非破坏性分析 吡嗪酰胺 |
| 文章编号： | 1671-5497（2006）03-0443-04 |
| 收稿时间： | 2005-11-02 |
| 修稿时间： | 2006-03-24 |
Quantitative analysis of Pyrazinamide tablets by near infrared spectroscopy with PLS regression |
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| Teng Le-sheng,Nian Zong-qian,Lu Jia-hui,Guo Wei-liang,Jiang Chao-jun,Meng Qing-fan.Quantitative analysis of Pyrazinamide tablets by near infrared spectroscopy with PLS regression[J].Journal of Jilin University:Eng and Technol Ed,2006,36(3):443-0446. |
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| Authors: | Teng Le-sheng Nian Zong-qian Lu Jia-hui Guo Wei-liang Jiang Chao-jun Meng Qing-fan |
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| Affiliation: | Department of Biopharmacy, College of Life Science, Jilin University, Changchun 130012, China |
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| Abstract: | Near infrared diffuse reflectance spectroscopy with partial least square fitting(NIRS-PLS) was applied for nondestructive quantification of the content of Pyrazinamide in Pyrazinamide tablets.A mathematical calibration model of NIRS was proposed using the first derivative spectrum in the wavelength range from 800 to 1200 nm.For this model,the regression coefficient(R) between predicted values and actual values in calibration set is as high as 0.9989 and the root mean-square error of prediction(RMSEP) is 0.563.Results show that this model is reliable with high prediction accuracy and is convenient for use,that can be used as general means in pharmaceutical analysis. |
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| Keywords: | pharmacochemistry near infrared spectroscopy partial least squares nondestructive analysis pyrazinamide |
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