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| 一例Citrin缺陷病患儿棘形红细胞的扫描电镜观察 | |
| 引用本文： | 曹水良,宋元宗,王自能,郭祖文,唐福星.一例Citrin缺陷病患儿棘形红细胞的扫描电镜观察[J].电子显微学报,2011,30(3):250-252. |
| 作者姓名： | 曹水良 宋元宗 王自能 郭祖文 唐福星 |
| 作者单位： | 1. 暨南大学 电镜室 广东广州510632 2. 暨南大学 附属第一医院儿科,广东广州,510630 3. 暨南大学 医学院妇产科教研室,广东广州,510632 |
| 基金项目： | 国家自然科学基金资助项目(No.81070279) |
| 摘 要： | 目的：探讨Citrin缺陷导致的新生儿肝内胆汁淤积症（NICCD）红细胞形态变化。方法：抽取一例NICCD患儿治疗前和治疗后的静脉血作为研究对象,应用扫描电镜和透射电镜观察红细胞的超微结构。结果：在扫描电镜下,该NICCD患者治疗前正常红细胞数百分比仅为1.4%,而棘形红细胞高达红细胞总数的95.6%,其它异形红细胞为3.2%。治疗后,视野内几乎均为正常红细胞,偶见棘形红细胞。在透射电镜下,治疗前红细胞膜表面有棘状突起,治疗后红细胞膜表面光滑,大部分红细胞切面呈棒状。结论：该例NICCD患儿治疗前棘形红细胞显著增加,治疗后红细胞形态恢复为双凹圆盘形,提示红细胞超微结构改变。可作为Citrin缺陷病的临床病理诊断辅助指征。 |
| 关 键 词： | Citrin缺陷 红细胞 扫描电镜 棘形红细胞 |
SEM observation on echinocytes in a Citrin-deficient infant |
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| CAO Shui-liang,SONG Yuan-zong,WANG Zi-neng,GUO Zu-wen,TANG Fu-xing.SEM observation on echinocytes in a Citrin-deficient infant[J].Journal of Chinese Electron Microscopy Society,2011,30(3):250-252. | |
| Authors: | CAO Shui-liang SONG Yuan-zong WANG Zi-neng GUO Zu-wen TANG Fu-xing |
| Affiliation: | CAO Shui-liang1,SONG Yuan-zong2,WANG Zi-neng3,GUO Zu-wen1,TANG Fu-xing1(1.Laboratory of Electron Microscopy,Jinan University,Guangzhou Guangdong 510632,2.Department of Pediatrics,the First Affiliated Hospital,Guangzhou Guangdong 510630,3.Department of Gynecology and Obstetrics,China) |
| Abstract: | Objective:To study the morphological changes of erythrocytes in a case of neonatal intrahepatic cholestasis caused by citrin deficiency(NICCD).Methods: Venous blood samples were collected from a NICCD patient.Erythrocytes before and after treatment were observed under scanning electron microscope(SEM).Results:Under SEM,the percentage of normal erythrocytes was only 1.4%,while echinocytes took account for a proportion of 95.6%,and other abnormal erythrocytes were 3.2% in total erythrocytes before treatment.A... |
| Keywords: | citrin deficiency erythrocyte scanning electron microscope echinocytes |
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