| DL-[4-~3H]-苯丙氨酸的制备 |
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| 引用本文： | 尤大伟,范国平. DL-[4-~3H]-苯丙氨酸的制备[J]. 核技术, 1985, 0(5) |
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| 作者姓名： | 尤大伟 范国平 |
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| 作者单位： | 中国科学院上海原子核研究所(尤大伟)，中国科学院上海原子核研究所(范国平) |
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| 摘 要： | DL-[4-~3H]-苯丙氨酸是生物化学、遗传工程等广为使用的氚标记化合物之一。以前大都采用N-乙酰胺基肉桂酸的催化氚化来制备。此方法工艺流程长、操作复杂。为此,我们采用了催化卤-氚交换法来制备DL-[4-~3H]-苯丙氨酸,并获得了成功。比放射性为16.6Ci/mmol,产品经三种溶剂系统纸层析和放射性扫描测定放化纯度均在95％以上。
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| 关 键 词： | 氚标记 卤氚交换 放射性层析扫描 苯丙氨酸 |
Preparation of DL-[4-~3H]-phenylalanine |
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| You Dawei Fan Guoping. Preparation of DL-[4-~3H]-phenylalanine[J]. Nuclear Techniques, 1985, 0(5) |
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| Authors: | You Dawei Fan Guoping |
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| Abstract: | DL-[4-3H]-phenylalanine was prepared by catalytic halogen-tritium exchange method The labelled T was removed by repeated equilibration with methanol and water. Finally the product was purified by paper chromatograph. The specific radioactivity of DL-[4-3H]-phenylalanine is 16.6 Ci/mmol. The radiochemical purity is more than 95%. |
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| Keywords: | tritium labelled halogen-tritium exchange radiochromatographic scan phenylalanine |
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