Obstructive sleep apnea syndrome in the Community of Valencia: current situation, study of needs and future prospects] |
| |
Authors: | E Chiner J Blanquer JM Arriero J Marco |
| |
Affiliation: | Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205, USA. |
| |
Abstract: | Experimental simian varicella virus (SVV) infection of St. Kitts vervet monkeys was evaluated as an animal model to investigate human varicella-zoster virus (VZV) infections. During the incubation period, viremia disseminated infectious virus throughout the body via infected peripheral blood lymphocytes (PBLs). A vesicular skin rash in the inguinal area, and on the abdomen, extremities, and face appeared on day 7-10 postinfection. Necrosis and hemorrhage in lung and liver tissues from acutely infected monkeys were evident upon histologic analysis. Recovery from simian varicella was accompanied by a rise in the serum neutralizing antibody response to the virus. SVV latency was established in trigeminal ganglia of monkeys which resolved the acute infection. This study indicates that experimental SVV infection of St. Kitts vervets is a useful animal model to investigate SVV and VZV pathogenesis and to evaluate potential antiviral agents and vaccines. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|