Molecular conjugate-mediated gene transfer into isolated human and transplanted rat kidneys |
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Authors: | ST Zeigler JD Kerby JA Thompson |
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Affiliation: | Department of Surgery, School of Medicine, University of Alabama at Birmingham 35294, USA. stephen.zeigler@ccc.uab.edu |
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Abstract: | Technically, renal transplantation has been feasible for over four decades. However, immunological injury to the transplanted kidney continues to be the leading cause of graft loss. While current immunosuppressive protocols yield a 1-year graft survival of > 90%, the trade off is increased risks from nephrotoxicity to manifestations of long-term immunosuppression. We have developed techniques which would allow genetic manipulation of the donor kidney while utilizing current procurement and preservation protocols. |
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