Protective Effect of Anthocyanin from Lonicera Caerulea var. Edulis on Radiation-Induced Damage in Mice |
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| Authors: | Haitian Zhao Zhenyu Wang Fengming Ma Xin Yang Cuilin Cheng Lei Yao |
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| Affiliation: | 1.School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China; E-Mails: (H.Z.); (F.M.); (X.Y.); (C.C.); (L.Y.);2.School of Forestry, Northeast Forestry University, Harbin 150040, China;3.National Research Center of Soybean Engineering and Technology, Northeast Agriculture University, Harbin 150030, China |
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| Abstract: | The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body 60Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application. |
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| Keywords: | anthocyanin Lonicera caerulea var. edulis 60Coγ radiation mice radioprotection |
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