Abstract: | Following a short discussion of the anatomopathological and clinical features of respiratory signs during systemic l.e., some clinical cases in which involvement of the respiratory system (pleural and/or parenchymal) was observed alone or was clearly predominant are reported. The cases also presented some unusual clinical characteristics. Clinical investigations must be extended to the systemic mesenchyma in the presence of pleuritis or pulmonary fibrosis of unclear aetiology, even where there are no extra-respiratory signs of S.L.E. |