Vitamin D Metabolic Pathway Components in Orthopedic Patientes—Systematic Review |
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Authors: | Janusz Pł omiń ski,Roman Grzybowski,Ewa Fiedorowicz,Edyta Sienkiewicz-Szł apka,Dominika Rozmus,Angelika Kró l-Grzymał a,Beata Jarmoł owska,Natalia Kordulewska,Anna Cieś liń ska |
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Affiliation: | 1.Clinical Department of Trauma—Orthopedic Surgery and Spine Surgery of the Provincial Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland;2.Department and Clinic of Orthopedics and Traumatology, Collegium Medicum, University of Warmia and Mazury, 10-719 Olsztyn, Poland;3.Faculty of Biology and Biotechnology, University of Warmia and Mazury, 10-719 Olsztyn, Poland |
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Abstract: | Vitamin D takes part in the functioning of many processes that ensure the homeostasis of the body. In orthopedics, it is indicated as an inseparable element ensuring proper bone growth and functioning, and its deficiencies are indicated in various diseases, mainly in the proper structure and function of the skeleton. In this review, we focus on the most important components of the vitamin D metabolic pathway, in correlation with selected orthopedic conditions. Records were obtained from the PubMed database in a timeline of 2010–2022. The keywords were as follows: vitamin D/cholesterol/vitamin D binding protein/ VDBP/Cytochrome/CYP24A1/CYP 27B1/Vitamin D receptor/VDR/ + diseases (ACL reconstruction, rotator cuff, arthroplasty knee/hip/shoulder). The recent original studies were analyzed, discussed, and the most important data were shown. The vast majority of articles concern the metabolite of vitamin D (25(OH)D), which is measured as a standard in diagnostic laboratories. Even though there is a lot of valuable information in the literature, we believe that the other elements of the vitamin D pathway also deserve attention and suggest their research in correlation with orthopedic disorders to supplement the missing knowledge on this topic. |
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Keywords: | vitamin D cholesterol VDBP CYP24A1 CYP27B1 VDR orthopedics ACL RC arthroplasty |
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