| Affiliation: | 1. Departamento de Química Orgánica and Instituto de Síntesis Orgánica (ISO)., Universidad de Alicante., Facultad de Ciencias, Apdo. 99, 03080 Alicante, Spain Dipartimento di Scienze Farmaceutiche, Università della Calabria., Edificio Polifunzionale, I-87036 Arcavacata di Rende (CS), Italy.;2. Departamento de Química Orgánica and Instituto de Síntesis Orgánica (ISO)., Universidad de Alicante., Facultad de Ciencias, Apdo. 99, 03080 Alicante, Spain;3. Dipartimento di Scienze Farmaceutiche, Università della Calabria., Edificio Polifunzionale, I-87036 Arcavacata di Rende (CS), Italy. |
| Abstract: | In the present study, for the first time environmentally friendly deep eutectic solvents (DESs) are used as reaction media to perform an efficient, simple and straightforward photocatalytic amide synthesis at room temperature using thioacids and amines. This method features mild conditions, a broad substrate scope, high yields (≤99%) under ambient conditions with air and moisture tolerance. Moreover, the applied operationally mild reaction conditions tolerate the presence of several different functional group substituents on the amine counterpart. Finally, the developed approach allows the recycling of the reaction medium and catalyst for at least three consecutive cycles without a significant decrease in the reaction yield. |
