日粮胆碱水平与宫内发育迟缓对猪肝脏抗氧化能力的影响

本实验旨在研究日粮胆碱水平与宫内发育迟缓（intrauterine growth retardation,IUGR）对猪生产性能及肝脏抗氧化指标的影响。从正常分娩的母猪中选择正常初生重（normal birth weight,NBW）和IUGR新生仔猪各12头,所有仔猪于23d龄断奶。实验采用2×2因子设计,NBW仔猪和IUGR仔猪各分别饲喂基础日粮（正常胆碱水平,NC）与添加胆碱的实验日粮（高胆碱水平,HC）,即NBW+NC、NBW+HC、IUGR+NC与IUGR+HC四组。结果表明:与NBW猪相比,IUGR显著降低了猪23d龄、73d龄及120d龄时的体重,猪200d龄时,IUGR组体重与正常组相比仍有降低趋势;IUGR有降低200d龄猪肝脏中T-AOC的趋势,并显著降低了肝脏清除DPPH·的能力（p<0.05）;高胆碱水平可显著降低肝脏中MDA的含量（p<0.05）,并使肝脏T-AOC、SOD的活性及清除DPPH·的能力显著升高（p<0.05）。结论:IUGR猪生长缓慢,高胆碱日粮可以改善肝脏抗氧化能力,使其在生长发育后期生长性能显著提高。 

Effect of dietary concentrations of choline and IUGR on hepatic anti-oxidation of pigs

The purpose of this study was to investigate the effect of dietary concentrations of choline and intrauterine growth retardation( IUGR) on growth performance and hepatic antioxidant parameters of pigs.Twelve normal body weight( NBW) piglets and twelve IUGR piglets were selected according to birth weight. At weaning( 23 d of age),both NBW and IUGR piglets were fed based diet or choline diet.Thus,all piglets were distributed into 4 treatments( NBW + NC,NBW + HC,IUGR + NC and IUGR + HC) × 6 piglets.Determination of body weight was performed at specified days,antioxidant parameters in the liver of pigs were measured at 200 d. The body weight of IUGR pigs were decreased significantly at 23,73,120d( p < 0.05),while compared with NBW pigs,there was a slight decrease in the body weight of IUGR pigs at 200 d. A tendency toward decreased T-AOC activity was observed in the liver of IUGR pigs,whilst IUGR significantly decreased the DPPH·scavenging activity in liver compared to NBW( p < 0.05).Consumption of the choline diet significantly increased the activities of T-AOC,SOD and DPPH· scavenging activity in the liver of pigs( p < 0.05),whilst hepatic MDA content was significantly decreased after choline treatment( p < 0.05). In conclusion,IUGR has a permanent stunting effect on growth performance of pigs and damages hepatic antioxidant ability.Notably,choline supplementation could ameliorate the harmful effects induced by IUGR.