HBeAg-negative hepatitis B in a previously thalassemic patient during immunosuppressive therapy for chronic GVHD |
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Authors: | S Kostaridou V Ladis A Kattamis A Laras SJ Hadziyannis |
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Affiliation: | First Department of Pediatrics, Aghia Sophia Children's Hospital, University of Athens, Greece. |
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Abstract: | We report the case of a 15-year-old previously thalassemic girl who, 15 months after allogeneic BMT, developed HBeAg-negative hepatitis B (variant with mu-1896). In the absence of another route of transmission, HBV reactivation is postulated. The time of emergence of the HBV variant (with mu-1896) is probably related to the development of anti-HBe immunity. This mutant strain is associated with fulminant hepatitis. The patient achieved complete remission and HBV eradication despite having moderate GVHD and receiving immunosuppressive therapy. |
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