| 三种保护苯甘氨酸衍生物的合成 |
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| 引用本文： | 金欣,李树彬.三种保护苯甘氨酸衍生物的合成[J].青岛科技大学学报,2009,30(3):217-220. |
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| 作者姓名： | 金欣 李树彬 |
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| 作者单位： | 青岛科技大学,化工学院,山东,青岛,266042
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| 基金项目： | 国家自然科学基金，青岛科技大学引进人才基金 |
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| 摘 要： | 以乙醛酸一水合物为起始原料通过芳环上的胺烷基化反应合成了3种苯环上带有易离去官能团的保护苯甘氨酸衍生物:N-苯甲酰基-4-溴苯甘氨酸甲酯、N-苄氧酰基-4-对甲苯磺酰氧基苯甘氨酸苄酯和N-苄氧酰基-4-三氟甲磺酰氧基苯甘氨酸苄酯,合成的3种化合物的总收率分别为39.3%、67.4%和66.7%。产物结构采用IR,1H NMR和13C NMR进行了鉴定。
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| 关 键 词： | 氨基酸 苯甘氨酸 保护基 衍生物 |
Synthesis of Three Protected Phenylglycine Derivatives |
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| JIN Xin,LI Shu-bin.Synthesis of Three Protected Phenylglycine Derivatives[J].Journal of Qingdao University of Science and Technology:Natutral Science Edition,2009,30(3):217-220. |
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| Authors: | JIN Xin LI Shu-bin |
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| Affiliation: | College of Chemical Engineering;Qingdao University of Science and Technology;Qingdao 266042;China |
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| Abstract: | Three protected phenylglycine derivatives with easy leaving groups,methyl 4-bromo-N-benzoylphenylglycinate,benzyl N-benzyloxycarbonyl-4-(p-toluenesulfonyloxy) phenylglycinate and benzyl N-benzyloxycarbonyl-4-trifluoromethanesulfonyloxyphenylglycinate,were synthesized by amidoalkylation of aromatic compounds using glyoxylic acid monohydrate as starting material.Effects of some factors on reaction yield were discussed.The yields of compounds were 39.3%,67.4% and 66.7%,respectively.The structures of the produc... |
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| Keywords: | amino acids phenylglycine protecting group derivatives |
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