Distant entry pneumothorax in a competitive fencer |
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Authors: | PA Harmer J Moriarity M Walsh M Bean J Cramer |
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Affiliation: | Department of Pharmacology, Albert Szent-Gy?rgyi Medical University, Szeged, Hungary. |
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Abstract: | Glibenclamide or glimepiride pretreatment (5 mg/kg i.p. 30 min prior to coronary ligation) significantly improved the survival rate during reperfusion after 6 min myocardial ischaemia in rats (82% or 67% vs. 17% in controls). Smaller dose of glibenclamide (0.01 mg/kg) did not influence the survival rate (31%), while glimepiride still offered a significant protection (61%). These results suggest that different KATP inhibitors may increase the chance to survive life-threatening arrhythmias during myocardial ischaemia-reperfusion. |
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