定量刻画冷冻手术中生物组织损伤度的熵产理论

从不可逆热力学角度出发，建立了有一定通用性、能涵盖各类冻融损伤要素的熵产理论分析方法。基于经典Pennes生物传热方程，导出了描述活体组织传热过程熵产率的热力学模型，初步提出了用以刻画低温手术过程中组织冻融损伤程度的公式，在此基础上，采用有限元数值计算并借助熵产公式，就血液灌注率、代谢产热及手术时间等因素对手术疗效的影响进行了考察，为从组织层次定量刻画低温手术过程中的冻融损伤提供了新的理论途径。

Entropy generation theory to quantify the damage degree of tissues subject to cryosurgical treatment

From non-equilibrium thermodynamics, a generalized entropy generation theory including mul- tiple factors involved in the freezing/heating process was proposed to evaluate the cryosurgical treatment efficiency. Starting from the well-known Pennes bioheat model, the entropy generation rate equation for characterizing the transport process of living tissues was derived, which has taken into consideration of the living properties such as blood perfusion and metabolic rate. Several correlations were preliminarily suggested to quantify the damage degree thus involved. Further, the finite element method was implemented to solve the transient phase change bioheat transfer problem as well as the entropy generation equation during cryosurgical freezing and rewarming. Effects of the above physiological and thermal parameters were then evaluated.