Ruthenium(III) Complexes of Heterocyclic Tridentate (ONN) Schiff Base: Synthesis,Characterization and its Biological Properties as an Antiradical and Antiproliferative Agent |
| |
Authors: | Ikechukwu P Ejidike Peter A Ajibade |
| |
Affiliation: | Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, P.B. X1314, Alice 5700, South Africa; |
| |
Abstract: | The current work reports the synthesis, spectroscopic studies, antiradical and antiproliferative properties of four ruthenium(III) complexes of heterocyclic tridentate Schiff base bearing a simple 2′,4′-dihydroxyacetophenone functionality and ethylenediamine as the bridging ligand with RCHO moiety. The reaction of the tridentate ligands with RuCl3·3H2O lead to the formation of neutral complexes of the type Ru(L)Cl2(H2O)] (where L = tridentate NNO ligands). The compounds were characterized by elemental analysis, UV-vis, conductivity measurements, FTIR spectroscopy and confirmed the proposed octahedral geometry around the Ru ion. The Ru(III) compounds showed antiradical potentials against 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, with DPPH scavenging capability in the order: (PAEBOD)RuCl2] > (BZEBOD)RuCl2] > (MOABOD)RuCl2] > Vit. C] > rutin] > (METBOD)RuCl2], and ABTS radical in the order: (PAEBOD)RuCl2] < (MOABOD)RuCl2] < (BZEBOD)RuCl2] < (METBOD)RuCl2]. Furthermore, in vitro anti-proliferative activity was investigated against three human cancer cell lines: renal cancer cell (TK-10), melanoma cancer cell (UACC-62) and breast cancer cell (MCF-7) by SRB assay. |
| |
Keywords: | tridentate Schiff base heterocyclic Ru(III) complexes spectroscopy antiradical antiproliferative |
|
|