| 2-羟乙基氨基-4-乙基-4,5-二氢噁唑啉的合成 |
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| 引用本文： | 侯学会,童岩,张京玉. 2-羟乙基氨基-4-乙基-4,5-二氢噁唑啉的合成[J]. 化学试剂, 2012, 34(8): 759-760,762 |
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| 作者姓名： | 侯学会 童岩 张京玉 |
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| 作者单位： | 1. 郑州牧业工程高等专科学校质量检测与管理系,河南郑州,450011
2. 河南中医学院药学院,河南郑州,450001 |
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| 摘 要： | 以氨基醇和硫代羰基二咪唑为起始原料,通过环合、氯代、烷基化反应制得目标化合物。产品及中间体的结构经ESI-MS和1HNMR确证。该方法步骤简单、原料易得、条件温和、收率较高,适合制备类似结构的噁唑啉化合物。
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| 关 键 词： | 噁唑啉 硫代羰基二咪唑 合成 |
Preparation of novel derivative of 2-hydroxyethylamino- 4-ethyl-4, 5-dihydrooxazole |
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| HOU Xue-hui , TONG Yan , ZHANG Jing-yu. Preparation of novel derivative of 2-hydroxyethylamino- 4-ethyl-4, 5-dihydrooxazole[J]. Chemical Reagents, 2012, 34(8): 759-760,762 |
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| Authors: | HOU Xue-hui TONG Yan ZHANG Jing-yu |
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| Affiliation: | 1.Department of Quality Detection and Management,Zhengzhou College of Animal Husbandry Engineering,Zhengzhou 450011,China;2.School of Pharmacy,Henan University of Traditional Chinese Medicine,Zhengzhou 450001,China) |
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| Abstract: | 2-Hydroxyethylamino-4-ethyl-4,5-dihydrooxazole was synthesized from 2-aminobutan-1-ol and di(1H-imidazol-1-yl)methanethione via cycliztion reaction,cholination reaction and alkylation reaction.The overall yield reached 72.0%.The product and all intermediates were confirmed by 1HNMR and ESI-MS.The method has high industrial value due to its low production cost,convenient steps,simplicity and high yield. |
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| Keywords: | dihydrooxazole di(1H-imidazol-1-yl)methanethione synthesis |
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