| 2-(N-烷基胺甲酰基)-4-甲氧基吡啶的合成与表征 |
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| 引用本文： | 闫凤美,牛建兵,潘庆才.2-(N-烷基胺甲酰基)-4-甲氧基吡啶的合成与表征[J].化学试剂,2012,34(1):91-93. |
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| 作者姓名： | 闫凤美 牛建兵 潘庆才 |
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| 作者单位： | 黄淮学院化学化工系,河南驻马店,463000 |
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| 基金项目： | 河南省基础与前沿技术研究项目 |
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| 摘 要： | 4-氯-2-吡啶甲酸甲酯与异丙胺、正丁胺通过胺解反应,制得相应的取代胺基甲酰基吡啶后,再与甲醇钠通过Wil-liamson合成法,得到标题化合物;详细考察了溶剂、反应温度对反应的影响;产品结构经IR、1HNMR、ESI-MS表征。
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| 关 键 词： | 4-氯-2-吡啶甲酸甲酯 胺解 Williamson合成法 2-(N-烷基胺甲酰基)-4-甲氧基吡啶 合成 表征 |
Synthesis and characterization of 4-methoxy-2-N-alkyl carbamoyl pyridine |
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| YAN Feng-mei
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NIU Jian-bing
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PAN Qing-cai.Synthesis and characterization of 4-methoxy-2-N-alkyl carbamoyl pyridine[J].Chemical Reagents,2012,34(1):91-93. |
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| Authors: | YAN Feng-mei NIU Jian-bing PAN Qing-cai |
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| Affiliation: | (Department of Chemistry and Chemical Engineering,Huanghuai University,Zhumadian 463000,China) |
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| Abstract: | Two 4-methoxy-2-N-alkyl carbamoyl pyridines were prepared from Williamson reaction between sodium methoxide and 4-chloropyridyl-2-formyl amide intermediates,which were synthesized starting from 4-chloropyridyl-2-carboxylic acid methyl ester,isopropylamine and butylamine.The effects of solvents and temperatures on the reaction were invisitigated.The structures of the compounds were confirmed by IR,1HNMR and ESI-MS. |
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| Keywords: | 4-chloropyridine-2-carboxylic acid methyl ester aminolysis Williamson method 4-methoxy-2-N-alkyl carbamoyl pyridine synthesis characterization |
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