有机锌试剂合成白藜芦醇新方法

以3,5-二羟基苯甲酸为原料,通过乙酰基保护、酰氯化、催化还原生成中间体3,5-二乙酰氧基苯甲醛,再与对乙酰氧基溴化苄经有机锌的烯基化反应,氢氧化钠脱乙酰基保护,得标题化合物,产率32.5％.首次利用无溶剂有机卤化锌试剂合成标题化合物,且该新方法原料廉价易得、条件温和、操作简单方便、绿色环保,因此,研究此方法具有十分重要的意义.

Total synthesis of resvertrol with organozinc halides

Resveratrol was synthesized from organozinc halides and 5-formyl-1,3-phenylene diacetate at the first time,the whole operation is economical,mild,and the raw materials is readily available,and the gross production rate is 32.5%.In which 5-formyl-1,3-phenylene diacetate was synthesized from 3,5-dihydroxy benzoic acid by protection of hydroxy acetoxy group,chloridation and reduction.