| 甘氨熊去氧胆酸的合成 |
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| 引用本文： | 龚启明,欧阳贵平. 甘氨熊去氧胆酸的合成[J]. 精细化工中间体, 2010, 40(2): 30-31 |
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| 作者姓名： | 龚启明 欧阳贵平 |
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| 作者单位： | 贵州大学,精细化工研究开发中心,贵州,贵阳,550025 |
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| 基金项目： | 贵州大学人才科研项目 |
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| 摘 要： | 以熊去氧胆酸为原料,先与氯甲酸乙酯形成混酐,再与甘氨酸乙酯反应合成甘氨熊去氧胆酸乙酯,最后水解得到甘氨熊去氧胆酸,产物结构经过IR、1HNMR确证。使用了廉价试剂,优化了合成方法,收率达到90.2%。
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| 关 键 词： | 熊去氧胆酸 甘氨熊去氧胆酸 氯甲酸乙酯 甘氨酸乙酯 合成 |
Synthesis of Glycoursodeoxycholic Acid |
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| GONG Qi-ming,OUYANG Gui-ping. Synthesis of Glycoursodeoxycholic Acid[J]. Fine Chemical Intermediates, 2010, 40(2): 30-31 |
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| Authors: | GONG Qi-ming OUYANG Gui-ping |
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| Affiliation: | GONG Qi-ming, OUYANG Gui-ping (Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, China) |
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| Abstract: | Glycoursodeoxycholic acid could be synthesized in an overall yield of 90.2% by the following procedures. Firstly, a mixed anhydride of ursodeoxycholic acid and ethyl chloroformate was synthesized. Secondly,reaction of the anhydride with ethyl glycinate hydrochloride afforded the ethyl ester of the ursodeoxycholic acid. Finally, hydrolysis of the ester in ethanolic sodium hydroxide produced the title compound. The product was confirmed with IR and ^1H NMR. |
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| Keywords: | ursodeoxycholic acid glycoursodeoxycholic acid ethyl chloroformate ethyl glycinate synthesis |
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