Alcohol-induced conditioned aversion: Genotypic specificity in mice (Mus musculus).

Previous studies show that acetaldehyde poisoning from ethanol ingestion may lead to aversion to ethanol among DBA mice but not among C57 mice, since the former are relatively deficient in aldehyde dehydrogenase activity. The present study paired ingestion of saccharin with a single intraperitoneal injection of 1 of 4 concentrations of ethanol for 60 DBA/2J and 60 C57BL/6J mice. Ss were then given a 2-bottle saccharin vs water preference test for 10 days. Substitution of saccharin for the taste of ethanol resulted in avoidance of saccharin with all concentrations of ethanol by DBAs but not by C57s, consistent with the conditioned taste aversion paradigm as a model for genetically mediated ethanol avoidance. (16 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)