| Abstract: | The effect of val5-angiotensin II amide on water drinking in sheep was studied against a background of comprehensive data on arterial blood and cerebrospinal fluid angiotensin II levels in sheep under a variety of physiological conditions. 10 sheep of Corriedale or Merino breeds were used in Exp I and 4 in Exp II; 5 ewes were used in Exp III. Physiological range of blood angiotensin II concentration is 1-100 ng/100 ml. Intravenous infusion of angiotensin II within the physiological range did not increase water drinking. Intracarotid infusion of angiotensin II, or injection into 3rd ventricle or hypothalamus, consistently caused immediate drinking of large amounts of water. Dosages necessary for effect were in the supraphysiological range. Quantitative examination of data in sheep and other species suggests that a physiological role for angiotensin II in thirst is not proved. (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) |
