| Abstract: | Investigated the involvement of indole- and catecholamines in the hormonal regulation of sexual receptivity in ovariectomized Sprague-Dawley rats. Drugs that reduce 5-hydroxytryptamine, dopamine, and adrenaline or increase noradrenaline neurotransmission tended to facilitate the occurrence of estrous behavior in estrogen-treated Ss, and drugs having opposite effects tended to inhibit receptivity induced by estrogen and progesterone. Estrogen decreased noradrenaline turnover in cortex and brain stem; progesterone enhanced this effect in brain stem but prevented it in cortex. Both hormones tended to block noradrenaline uptake in hypothalamus in vitro. In a schedule used to induce receptivity, estrogen accelerated serotonin turnover, an effect prevented by progesterone. Results suggest that a number of monoamines may be involved in the control by hormones of estrous behavior and that hormones affect both amine turnover and uptake mechanisms. (85 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) |
