Thermoreversible hydrogels XIII: Synthesis and swelling behaviors of [N-isopropylacrylamide-co-sodium 2-acrylamido-2-methylpropyl sulfonate-co-N,N-dimethyl(acrylamido propyl) ammonium propane sulfonate] copolymeric hydrogels |
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Authors: | Wen-Fu Lee Wen-Yang Yuan |
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Affiliation: | (1) Department of Chemical Engineering, Tatung University, Taipei, 10451, Taiwan, Republic of China |
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Abstract: | A series of copolymeric hydrogels were prepared from various molar ratios of N-isopropylacrylamide (NIPAAm), sodium-2-acrylamido-2-methylpropyl sulfonate (NaAMPS) and N,N′-dimethyl(acrylamido propyl) ammonium propane sulfonate (DMAAPS). The swelling behaviors of these copolymeric hydrogels were
investigated in various saline solutions. The result showed that the phase transition temperatures of these gels changed insignificantly,
and the thermosensitivity, in contrast, diminished. In addition, the copolymer gels exhibited polyelectrolytic behavior under
lower salt concentration (10−5∼10−1 M), exhibited a nonionic gel (like NIPAAm) behavior at the salt concentration from 0.1 to 0.4 M, and showed an antipolyelectrolytic
behavior (polyzwitterionic effect) at a salt concentration over 0.4 M. Finally, the presented coplymeric gels are investigated
for use in drug release application. |
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Keywords: | Hydrogels Zwitterionic sulfobetaine Anionic polyelectrolyte gels Drug release |
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