| 电离辐射诱发的基因组不稳定性和旁效应 |
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| 引用本文： | 耿晓华,王仲文.电离辐射诱发的基因组不稳定性和旁效应[J].辐射防护通讯,2005,25(6):15-21. |
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| 作者姓名： | 耿晓华 王仲文 |
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| 作者单位： | 山西大学生物技术研究所,太原,030006;中国辐射防护研究院,太原,030006 |
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| 摘 要： | 近10年来，对于基因组不稳定性和旁效应的研究已成为生物学和放射生物学领域的一个热点。随着对辐射损伤研究的深入，电离辐射引起的非靶效应（如基因组不稳定性、旁效应等）将对与辐射照射有关的危险评价提出新的挑战。本文就体内、外电离辐射诱发的基因组不稳定性，体内、外旁效应以及二者之间的关系做一简要概述。
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| 关 键 词： | 电离辐射 非靶效应 基因组不稳定性 旁效应 |
| 文章编号： | 1004-6356（2005）06-0015-07 |
| 收稿时间： | 2005-10-24 |
| 修稿时间： | 2005年10月24 |
Ionizing Radiation Induced Genomic Instability and Bystander Effects |
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| Geng Xiaohua,Wang Zhongwen.Ionizing Radiation Induced Genomic Instability and Bystander Effects[J].Radiation Protection Bulletin,2005,25(6):15-21. |
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| Authors: | Geng Xiaohua Wang Zhongwen |
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| Affiliation: | 1.Institute of Bio-technology, Shanxi University, Taiyuan, 030006;2.China Institute for Radiation Protection, Taiyuan, 030006 |
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| Abstract: | In past decade,the researches on genomic instability and bystander effects have become a hotspot of biology and radiobiology.With further researches on radiation damage,non-targeted effects(such as genomic instability and bystander effects) induced by ionizing irradiation will pose new challenges to evaluating risk(s) associated with radiation exposure.This article makes a brief outline on radiation-induced genomic instability in vivo and in vitro,bystander effects in vivo and in vitro,and the relationship between genomic instability and bystander effects. |
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| Keywords: | Ionizing radiation Non-targeted effects Genomic instability Bystander effects |
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