| L-脯-L-亮-甘氨酰胺(PLG)的离子束氚标记及其在鼠脑内的分布 |
| |
| 引用本文： | 俞斌伟,张年宝,谢炳华,秦锐芳,钟德松,要福增,蔡海鸥,徐德隆,余慧贞,王增.L-脯-L-亮-甘氨酰胺(PLG)的离子束氚标记及其在鼠脑内的分布[J].核技术,1990(11). |
| |
| 作者姓名： | 俞斌伟 张年宝 谢炳华 秦锐芳 钟德松 要福增 蔡海鸥 徐德隆 余慧贞 王增 |
| |
| 作者单位： | 中国科学院上海原子核研究所
(俞斌伟，张年宝，谢炳华，秦锐芳，钟德松，要福增)，上海第二医科大学附属瑞金医院
(蔡海鸥，徐德隆，余慧贞)，上海第二医科大学附属瑞金医院(王增) |
| |
| 摘 要： | 本文用离子束氚标记技术制得氚标记PLG。经磋胶纸层析法纯化,氚化三肽的比活度为6.81GBq/mmol,放化纯度>95％,具有完全的生物活性。由腹腔注射~3H-PLG,直接测定大鼠脑内部分组织的放射性分布,提示用药4.5h后,垂体、纹状体有较高的放射性,而下丘脑和中脑的放射性较低。
|
| 关 键 词： | 氚标记 L-脯-L-亮-甘氨酰胺 帕金森病 分布 |
Ion beam tritium labelling of L-prolyl-L-leucyl-glycinamide and its distribution in rat brain |
| |
| Yu Binwei Zhang Nianbao Xie Binghua Qin RuifangZhong Desong Yao Fuzeng.Ion beam tritium labelling of L-prolyl-L-leucyl-glycinamide and its distribution in rat brain[J].Nuclear Techniques,1990(11). |
| |
| Authors: | Yu Binwei Zhang Nianbao Xie Binghua Qin RuifangZhong Desong Yao Fuzeng |
| |
| Abstract: | Tritium labelled L-prolyl-L-leucyl-glycinamide(3H-PLG) was prepared by ion beam method and purified by thin-layer chromatogrphy. After removal of all tritum the tritia-tcd tripeptide was obtained with a specific radioactivity of 0.81-1.92GBq/mmol. The radiochemical purity was over 95% and biological activity remained unchanged. The distribution of radioactivity after intraperitoneal injection of 3H-PLG has been studied by direct measurement of radioactivity in different parts brain. The uptake of radioactivity was high in pituitary and striatum and was low in hypothalamus and midbrain. |
| |
| Keywords: | Tritium labelling of L-prolyl-L-leudyl-glycinamide Parkinson'sdisease Distribution |
| 本文献已被 CNKI 等数据库收录！ |
