A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus |
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| Authors: | VM Aita J Liu JA Knowles JD Terwilliger R Baltazar A Grunn JE Loth K Kanyas B Lerer J Endicott Z Wang G Penchaszadeh TC Gilliam M Baron |
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| Affiliation: | Department of Genetics and Development, Columbia University, New York, USA. |
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| Abstract: | Previously, we demonstrated evidence of linkage to bipolar affective disorder (BP) in a single large, multigenerational family with a LOD score of 3.41 at the PFKL locus on chromosome 21q22.3. Additional families showed little support for linkage to PFKL under homogeneity or heterogeneity, in that study. We have expanded on that analysis, with 31 microsatellite markers at an average marker spacing of
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