| 对映选择性氢化法合成苯甘氨酸甲酯 |
| |
| 引用本文： | 刘鹏,江焕峰,刘海灵,王玉刚,杨少容.对映选择性氢化法合成苯甘氨酸甲酯[J].精细化工,2004,21(11):844-846. |
| |
| 作者姓名： | 刘鹏 江焕峰 刘海灵 王玉刚 杨少容 |
| |
| 作者单位： | 1. 中国科学院,广州化学研究所,广东,广州,510650
2. 华南理工大学,应用化学系,广东,广州,510640 |
| |
| 基金项目： | 国家自然科学基金资助项目(No:20332030，20172053)~~ |
| |
| 摘 要： | 以α 肟基苯乙酸甲酯为原料,硫酸奎宁为修饰剂,通过Pd/C催化氢化合成苯甘氨酸甲酯。考察了反应温度、溶剂、修饰剂的量对对映选择性的影响。最佳反应条件:25～28℃、乙醇为溶剂、氢气压力101 325kPa、n(修饰剂)∶n(底物)=1∶10,苯甘氨酸甲酯的光学产率达51 3%。
|
| 关 键 词： | 苯甘氨酸甲酯 对映选择性氢化 硫酸奎宁 钯/碳 |
| 文章编号： | 1003-5214(2004)011-0844-03 |
Synthesis of Phenylglycine Methyl Ester via Catalytic Hydrogenation |
| |
| LIU Peng,JIANG Huan-feng.Synthesis of Phenylglycine Methyl Ester via Catalytic Hydrogenation[J].Fine Chemicals,2004,21(11):844-846. |
| |
| Authors: | LIU Peng JIANG Huan-feng |
| |
| Affiliation: | LIU Peng~1,JIANG Huan-feng~ |
| |
| Abstract: | The enantioselective hydrogenation of 1-hydroxyimino-1-phenylacetic acid methyl ester to phenylglycine methyl ester was studied on Pd/C modified by quinine sulfate.Effects of reaction conditions such as temperature,solvent and amount of the modifier on reaction rate and enantioselectivity were examined.The optimum reaction conditions were:r.t.,hydrogenation pressure of 101.325 kPa and n(quinine sulfate)∶n(oxime)=1∶10.The optical yield of phenylglycine methyl ester was up to 51.3%. |
| |
| Keywords: | phenylglycine methyl ester enantioselective hydrogenation quinine sulfate Pd/C |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
