Short Term Dietary Fish Oil Supplementation Improves Motor Deficiencies Related to Reserpine-Induced Parkinsonism in Rats |
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Authors: | Raquel Cristine Silva Barcelos Dalila Moter Benvegnú Nardeli Boufleur Camila Pase Angélica Martelli Teixeira Patrícia Reckziegel Tatiana Emanuelli João Batista T da Rocha Marilise Escobar Bürger |
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Affiliation: | 1.Departamento de Fisiologia e Farmacologia,Universidade Federal de Santa Maria (UFSM),Santa Maria,Brazil;2.Programa de Pós-Gradua??o em Farmacologia, Centro de Ciências da Saúde,Universidade Federal de Santa Maria (UFSM),Santa Maria,Brazil;3.Programa de Pós-Gradua??o em Bioquímica Toxicológica,UFSM,Santa Maria,Brazil;4.Programa de Pós Gradua??o em Ciência e Tecnologia dos Alimentos, Centro de ciências Rurais,UFSM,Santa Maria,Brazil |
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Abstract: | Fish oil (FO) supplementation could cause an increase in the concentration of plasmatic free fatty acids and, consequently,
could compete with pro-inflammatory arachidonic acid (ARA) derived from brain biomembranes metabolism in the cerebrospinal
fluid. Essential fatty acids (EFA) (n-3) have been reported by their antioxidant and neuroprotective properties, and therefore
the influence of the FO supplementation on the reserpine-induced motor disorders was studied. Wistar rats were orally treated
with FO solution for 5 days, and co-treated with reserpine (R; 1 mg/kg/mL) or its vehicle for 3 days (every other day). Reserpine-induced orofacial dyskinesia and catalepsy (P < 0.05) were prevented by FO (P < 0.05). Biochemical evaluations showed that reserpine treatment increased the lipid peroxidation in the cortex and striatum
(P < 0.05), while the FO supplementation prevented this oxidative effect in both brain regions (P < 0.05). Our results showed the protective role of FO in the brain lipid membranes, reinforcing the beneficial effect of
n-3 fatty acids in the prevention of degenerative and motor disorders. |
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