Applications of microsatellite-based Y chromosome haplotyping |
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Authors: | M Kayser P de Knijff P Dieltjes M Krawczak M Nagy T Zerjal A Pandya C Tyler-Smith L Roewer |
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Affiliation: | Institut für Gerichtliche Medizin, Humboldt-Universit?t zu Berlin, Germany. kayser@rz.charite.hu-berlin.de |
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Abstract: | Y-chromosomal microsatellites have been investigated for the purposes of application to male identification, population genetics and population history. With nine markers, every male in a German population sample (n = 70) could be identified by an individual-specific Y microsatellite haplotype. The analysis of 474 unrelated males of nine human populations with seven markers revealed 301 different Y haplotypes. The analysis of molecular variance (AMOVA) approach was used to detect male population characteristics of Y microsatellite haplotypes. With pairwise comparisons of inter-population variance, most of the populations could be distinguished significantly. Sixty individuals from different male populations in Asia and Northern Europe carrying a novel Y-chromosomal T-->C transition show reduced microsatellite variability together with haplotype similarities. Microsatellite data suggest that the mutation occurred recently in Asia, supporting the hypothesis of Asian ancestry of some northern European populations. |
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