| 香豆素-3-羧酸烟醇酯的合成 |
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| 引用本文： | 李祥华,吴亚先,何黎琴. 香豆素-3-羧酸烟醇酯的合成[J]. 安徽化工, 2015, 0(1). DOI: 10.3969/j.issn.1008-553X.2015.01.007 |
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| 作者姓名： | 李祥华 吴亚先 何黎琴 |
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| 作者单位： | 安徽中医学院药学院,安徽合肥,230031 |
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| 基金项目： | 安徽省教育厅自然科学重点科研项目 |
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| 摘 要： | 目的:为寻找抗动脉粥样硬化药物,合成香豆素-3-羧酸烟醇酯。方法:以水杨醛、丙二酸二乙酯为原料,合成得到香豆素-3-羧酸,再在脱水剂作用下与烟醇缩合,得到目标化合物香豆素-3-羧酸烟醇酯。结果与结论:设计合成了香豆素-3-羧酸烟醇酯,目标物的化学结构经IR、MS、1H-NMR等确证。
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| 关 键 词： | 香豆素-3-羧酸 烟醇 合成 |
Synthesis of Nicomethanol Coumarin-3-carboxylate |
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| LI Xiang-hua,WU Ya-xian,HE Li-qin. Synthesis of Nicomethanol Coumarin-3-carboxylate[J]. Anhui Chemical Industry, 2015, 0(1). DOI: 10.3969/j.issn.1008-553X.2015.01.007 |
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| Authors: | LI Xiang-hua WU Ya-xian HE Li-qin |
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| Abstract: | Objective:To search for effective antiatherogenic agent,Nicomethanol coumarin-3-carboxylate was synthesized. Methods: Salicylide reacted with diethyl malonate under piperidine catalysis,then coumarin-3-carboxylic acid was gained through hydrolysis and acidification. The target compound was obtained by coupling coumarin-3-carboxylic acid with nicotinyl alcohol in the presence of dehydration agents. Results and Conclusion:Nicomethanol coumarin-3-carboxylate was synthesized. The chemical structure of the target compound was confirmed by IR,MS,and 1H-NMR spectra. |
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| Keywords: | coumarin-3-carboxylic acid nicotinyl alcohol synthesis |
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