| 氯虫苯甲酰胺的合成 |
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| 引用本文： | 王艳军,张大永,吴晓明.氯虫苯甲酰胺的合成[J].农药,2010,49(3). |
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| 作者姓名： | 王艳军 张大永 吴晓明 |
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| 作者单位： | 中国药科大学药学院,南京,210009 |
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| 摘 要： | 以顺丁烯二酸酐、2,3-二氯吡啶为起始原料经8步反应合成中间体3-溴-1-(3-氯吡啶-2-吡啶基)-1H-吡唑-5-甲酸(9);以2-氨基-3-甲基苯甲酸为原料经1步反应合成中间体5-氯-2-氨基-3-甲基苯甲酸(10).中间体9与10反应生成氯虫苯甲酰胺.目标化合物经1H NMR确证.反应总收率36.3%(以2,3-二氯吡啶计),产品含量(HPLC)不小于95%.
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| 关 键 词： | 氯虫苯甲酰胺 杀虫剂 合成 |
Synthesis of Chlorantraniliprole |
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| WANG Yan-jun,ZHANG Da-yong,WU Xiao-ming.Synthesis of Chlorantraniliprole[J].Pesticides,2010,49(3). |
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| Authors: | WANG Yan-jun ZHANG Da-yong WU Xiao-ming |
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| Affiliation: | School of Pharmacy/a>;China Pharmaceutical University/a>;Nanjing 210009/a>;China |
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| Abstract: | Chlorantraniliprole was synthesized by reaction of 3-bromo-1-(3-chloropyridin-2-pyridinyl)-1H-pyrazole-5carboxylic acid with 2-amino-5-chloro-3-methylbenzoic acid.3-bromo-1-(3-chloropyridin-2-pyridinyl)-1H-pyrazole5-carboxylic acid was prepared by reaction of maleic anhydride with 2,3-dichloropyridine as starting materials in eight steps.2-Amino-5-chloro-3-methylbenzoic acid was prepared by reaction of 2-amino-3-methylbenzoic acid in one step.The structure of target compound was conf irmed by 1H NMR.Total y... |
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| Keywords: | chlorantraniliprole insecticide synthesis |
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