| 4-(4-氯苯基)环己醇及4-(4-氯苯基)环己酮的合成研究 |
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| 引用本文： | 王继华,王焕杰,马振东,任大永,王晔.4-(4-氯苯基)环己醇及4-(4-氯苯基)环己酮的合成研究[J].精细化工中间体,2007,37(2):48-51. |
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| 作者姓名： | 王继华 王焕杰 马振东 任大永 王晔 |
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| 作者单位： | 烟台万润精细化工有限责任公司,山东,烟台,264006 |
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| 摘 要： | 以氯苯、环己烯、乙酰氯为原料,通过Friedel-Crafts反应、Baeyer-Villiger反应、水解反应得到4-(4-氯苯基)环己醇。通过正交试验得到Friedel-Crafts反应和Baeyer-Villiger反应优化后的工艺条件。4-(4-氯苯基)环己醇总收率达12.9%,较文献收率提高了6%以上。所得醇经次氯酸钠氧化,得到4-(4-氯苯基)环己酮,氧化收率87%,产品的结构经1HNMR、GC-MS鉴定。
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| 关 键 词： | 4-(4-氯苯基)环己醇 4-(4-氯苯基)环己酮 合成 |
| 文章编号： | 1009-9212（2007）02-0048-04 |
| 修稿时间： | 2007-01-29 |
Synthesis of 4-(4-Chlorophenyl)cyclohexanol and 4-(4-Chlorophenyl)cyclohexanone |
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| WANG Ji-hua,WANG Huan-jie,MA Zhen-dong,REN Da-yong,WANG Ye.Synthesis of 4-(4-Chlorophenyl)cyclohexanol and 4-(4-Chlorophenyl)cyclohexanone[J].Fine Chemical Intermediates,2007,37(2):48-51. |
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| Authors: | WANG Ji-hua WANG Huan-jie MA Zhen-dong REN Da-yong WANG Ye |
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| Affiliation: | Yantai Valiant Fine Chemicals Co.,Ltd., Yantai 264006, China |
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| Abstract: | 4-(4-Chlorophenyl)cyclohexanol was synthesized from chlorobenzene,cyclohexene and acetyl chloride via Friedel-Crafts reation,Baeyer-Villiger reaction ,hydrolysis. By experiments utilizing an orthogonal design,optimum synthesis conditions of Friedel-Crafts reation and Baeyer-Villiger reaction were obtained. The total yield of 4-(4-chlorophenyl)cyclohexanol is 12.9%,which is 6% higher than the literature. 4-(4-chlorophenyl)cyclohexanol was oxidated with NaClO to give 4-(4-chlorophenyl)cyclohexanone with yield of 87%. This is a new synthesis route for 4-(4-chlorophenyl)cyclohexanone. The products were identified by 1H NMR,GC-MS. |
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| Keywords: | 4-(4-chlorophenyl)cyclohexanol 4-(4-chlorophenyl)cyclohexanone synthesis |
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