Porous TiO2 films on Ti implants for controlled release of tetracycline-hydrochloride (TCH) |
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| Authors: | Cheol-Min HanEun-Jung Lee Hyoun-Ee Kim Young-Hag KohJun-Hyeog Jang |
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| Affiliation: | a WCU Hybrid Materials Program, Department of Materials Science and Engineering, Seoul National University, Seoul, 151-744, Republic of Koreab Department of Dental Laboratory Science and Engineering, Korea University, Seoul, 136-706, Republic of Koreac Department of Biochemistry, School of Medicine, Inha University, Incheon, 400-712, Republic of Korea |
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| Abstract: | Micro- and nano-porous TiO2 films were created on the surface of Ti implants using micro-arc oxidation and anodic titanium oxide treatments, respectively, to load a sol-gel derived silica xerogel for the controlled release of the antibiotic drug, tetracycline-hydrochloride (TCH). When the silica xerogel containing TCH was loaded into porous TiO2 films, a very high drug loading efficiency was observed compared to when it was loaded in Ti implants without a TiO2 film. Moreover, TCH was released in a controlled manner for up to 7 days. |
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| Keywords: | Micro-arc oxidation Anodic titanium oxide Silica xerogel Controlled drug release |
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