2-甲基-2-噁唑啉的合成研究

以N-(2-羟基乙基)乙酰胺为原料,在二水乙酸锌的催化作用下,脱水缩合生成2-甲基-2-噁唑啉,考察了温度、催化剂用量、压力、时间对反应的影响。最佳工艺条件为:m(催化剂):m(N-(2-羟基乙基乙酰胺))=0.15∶1,反应温度为185℃,压力为0.01 MPa,反应时间为2 h,收率可达到95%。并考察了催化剂的重复使用情况。产物经质谱进行了结构表征。

Synthesis of 2-Methyl-2-oxazoline

2-Methyl-2-oxazoline was prepared from N-(-2-hydroxyethyl)-acetamide using zinc acetate hydrate as catalyst.The effect of catalyst amount,reaction temperature,reaction time and reaction pressure was studied.The optimum reaction conditions were:m(catalyst):m(N-(2-hydroxyethyl)-acetamide)=0.15:1;reaction temperature,185℃;reaction pressure,0.01 MPa;reaction time,about 2 h.The vield of 2-methyl-2-oxazoline can reach 92%.The reuse of catalyst was investigated.The product was identified by MS.