Effect of five cysteine-containing compounds on three lipogenic enzymes in Balb/cA mice consuming a high saturated fat diet |
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Authors: | Chun-che?Lin Email author" target="_blank">Mei-chin?YinEmail author Cheng-chin?Hsu Meng-pei?Lin |
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Affiliation: | (1) Department of Internal Medicine, Chungshan Medical University Hospital, Taichung City, Taiwan, Republic of China;(2) Department of Nutritional Science, Chungshan Medical University, No. 110, Sec. 1, Chien-Kuo N. Rd., Taichung City, Taiwan, R.O.C. |
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Abstract: | The in vivo effects of N-acetyl cysteine (NAC), S-allyl cysteine, S-ethy cysteine (SEC), S-methyl cysteine (SMC), and S-propyl cysteine
(SPC) against hyperlipidemia development and oxidation stress in Balb/cA mice consuming a high saturated fat diet were examined.
The influence of these agents on plasma levels of glucose, insulin, uric acid, TG, cholesterol, and the activity of three
lipogenic enzymes—glucose-6-phosphate dehydrogenase, malic enzyme, and FA synthase—was determined. All mice consumed the coconut
oil-basd, high saturated fat diet, water, and cysteine or one of the five cysteine-containing compounds for 4 wk. The diet
with 18% saturated fat significantly elevated the activity of three lipogenic enzymes and significantly increased TG and cholesterol
biosynthesis in plasma and liver (P<0.05). When compared with the water and cysteine groups, the treatments from five cysteine-containing agents significantly
reduced high saturated fat diet-increased malic enzyme and FA synthase activities, and significantly lowered TG levels in
plasma and liver (P<0.05); however, only NAC, SAC, and SMC treatments significantly reduced cholesterol levels in plasma and liver (P<0.05). The five cysteine-containing agents significantly restored high saturated fat diet-decreased glutathione peroxidase
(GPX) activity in liver (P<0.05); however, only SMC and SPC significantly restored GPX activity in heart and kidney (P<0.05). These agents also significantly improved high saturated fat diet-related hyperglycemia, hyperuricemia, and oxidation
stress (P<0.05). These data support the hypothesis that these compounds are potential multiply-protective agents for hyperlipidemia
prevention or therapy. |
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