Perinatal asphyxia and heart problems |
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| Authors: | GV Herdy VG Lopes ML Arag?o CA Pinto PA Tavares Júnior FB Azeredo PM Nascimento |
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| Affiliation: | Department of Pharmaceutical Sciences, University of Padova, Italy. |
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| Abstract: | New bisantrene analogues were synthesized, bearing one or two 4,5-dihydro-1H-imidazol-2-yl hydrazone side chains at positions 1,4 or 9 of the anthracene ring system. A 10-azabioisostere was also prepared. The position of substituents in structurally isomeric drugs modulates topoisomerase II poisoning and specificity, along with cytotoxicity. |
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