Creutzfeldt-Jakob disease associated with autonomic nervous system dysfunction in the early stage |
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Authors: | E Nomura T Harada K Kurokawa Y Murata F Ishizaki Y Mimori S Nakamura |
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Affiliation: | Third Department of Internal Medicine, Hiroshima University School of Medicine, Minami-ku. |
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Abstract: | A 54-year-old man presented with tremor and unusual behavior. He was admitted two months later because of dementia and myoclonus. Periodic synchronous discharges were observed on the electroencephalogram. Based on these findings, we diagnosed the case as Creutzfeldt-Jakob disease. About two weeks after admission, decubitus, bowel dysfunction and hypohidrosis occurred. We observed various autonomic nervous system dysfunctions such as abnormal pupillary response to autonomic drugs, reduced coefficient of variation of R-R interval, and abnormal diurnal blood pressure variation. |
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