微流控光纤芯片的研究

微流控光纤芯片是一种把光纤植入到芯片中以方便检测的新型生物分析芯片，它利用光纤传输激发光，使激发光斑的直径大大减小，省去了光学会聚装置，缩小了检测系统的体积，提高了检测灵敏度。另外，它具有试剂消耗少、处理速度快、制作成本低、制作方法简单等优点，成为微全分析系统（μ-TAS）研究的热点。结合目前带光纤微流控芯片的发展状况，综述了两种类型芯片的制作方法及其所需材料，介绍了每种芯片的检测原理、结构及分类，分析了每种芯片的优点与不足，并探讨了其发展趋势。

Research of Microfluidic Fiber Chip

The microfluidic fiber chip, embeding the fibers in the chips for the convenience of detection, is a kind of new-style biology analysis chip. The fiber is used to transmit excitation light, so the diameter of the light spot is decreased greatly, the optics convergence device is spared, the bulk of the detection system is reduced, and the detection sensitivity is improved. In addition, due to less reagent used, high process speed, low cost and simple fabrication process, it becomes the hotspots in the research of miniaturized total analysis system. According to its developing status at present, the fabrication processes of two kinds of chips are introduced. The detection principles, structures, materials and specifications of each biochip are described. The merits and demerits of each chip are analyzed. A thorough overview of the developments in this field to date is provided.