| LABELING McAb 3H11 AND ITS Fab FRAGMENT WITH 211At AND THEIR IMMUNOREACTIVITIES AND INJURY EFFECTS ON HUMAN GASTRIC CANCER CELLS |
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| 作者姓名： | 刘宁 罗德元 |
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| 作者单位： | [1]InstituteofNuclearScienceandTechnology,SichuanUnionUniversity,Chengdu610064 [2]InstituteofCancerResearch,SichuanUnionUniversity,Chengdu610064 |
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| 摘 要： | An antigastric cancer monoclonal antibody,3H11,and its Fab fragment,were labeled using p-(211At)-astatobenzoic acid(pAtBA) intermediate,in the yields of more than 30%.The results of in vitro experiments show that ^211 At-3H11 and ^211At-3H11 Fab are stable,and have specific immunoreactivities and cytotoxic effects to human gastric cancer cell M85,The cytotoxic effects are dependent on the concentration of ^211At-3H11 or 211 At-3H11 Fab and obviously stronger than that of Na^211At.
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| 关 键 词： | 胃癌细胞 损伤效应 示踪方法 |
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