PEG对生物可降解聚氨酯性能影响的研究

以不同相对分子质量的聚乙二醇(PEG)为引发剂,通过开环聚合引发丙交酯和己内酯单体合成聚己内酯–丙交酯–聚乙二醇(PCLA–PEG)的共聚物;用六亚甲基二异氰酸酯(HDI)对合成的共聚物进行封端,并进行扩链反应制备一系列PEG含量不同的生物可降解聚氨酯。通过红外以及DSC研究了PEG含量对聚氨酯材料结构的影响,发现采用相对分子质量较高的PEG制备的材料,其软硬段相分离程度较高;另外对样品的力学性能、亲水性及降解性进行了测试,发现PEG含量增加,样品的力学性能下降,亲水性能提高,降解速度加快。

Research on Influence of PEG on Performance of Bio-Degradable Polyurethane

The poly(caprolactone-co-lactide)-polyethylene glycol (PCLA-PEG) co-polymers were synthesized by ring-opening polymerization initiated from lactide and caprolactone monomers using polyethylene glycol (PEG) with different relative molecular masses as initiator. The prepared co-polymers were end-capped by using hexamethylene diisocyanate (HDI), and the chain-extending reaction occurred further to prepare a series of bio-degradable polyurethanes with different PEG contents. The influence of PEG content on structures of polyurethane materials was investigated by using FT-IR and DSC. It is found that the polyurethane materials prepared with higher relative molecular mass PEG have higher phase separation degree between soft segments and hard segments. In addition, the mechanical performance, hydrophility and degradability of the samples were tested. It is found that the mechanical performance of the samples decreases, while the hydrophility and degradability of samples increase with increasing of PEG content.