| 庆大霉素普鲁卡因胃漂浮缓释微丸的制备及质量评价 |
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| 引用本文： | 王文喜,章哲文,李佳萍,方松桥,黄依依.庆大霉素普鲁卡因胃漂浮缓释微丸的制备及质量评价[J].浙江工业大学学报,2013,41(3):265-269. |
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| 作者姓名： | 王文喜 章哲文 李佳萍 方松桥 黄依依 |
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| 作者单位： | 浙江工业大学药学院,浙江杭州,310032 |
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| 摘 要： | 采用挤出滚圆法制备含药丸芯,运用流化床包衣技术对丸芯进行多层包衣以控制微丸的漂浮性和药物的释放特性,从而获得性能良好的庆大霉素普鲁卡因胃漂浮缓释微丸;利用紫外分光光度法测定普鲁卡因的含量和累积释放度,考察其体外漂浮和释药等性能.当m(普鲁卡因)∶m(庆大霉素)∶m(微晶纤维素)∶m(十八醇)∶m(NaHCO3)=10∶2∶20∶5∶1,以2%十二烷基硫酸钠为润湿剂时,所得丸芯圆整度较好;微丸包衣材料由内而外依次为尤特奇RS,NaHCO3和尤特奇RL,其增重分别为14.9%,10.2%和16.6%;所得微丸在人工胃液中迅速起漂,8h漂浮百分率超过90%,体外释放行为符合Higuchi扩散模型.结果表明:按本法制备的丸芯质量较好,所得包衣微丸达到了漂浮与缓释的双重要求.
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| 关 键 词： | 普鲁卡因 胃漂浮 缓释微丸 |
The preparation and evaluation of gentamycin and procaine gastric floating sustained-release pellets |
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| WANG Wen-xi
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ZHANG Zhe-wen
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LI Jia-ping
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FANG Song-qiao
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HUANG Yi-yi.The preparation and evaluation of gentamycin and procaine gastric floating sustained-release pellets[J].Journal of Zhejiang University of Technology,2013,41(3):265-269. |
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| Authors: | WANG Wen-xi ZHANG Zhe-wen LI Jia-ping FANG Song-qiao HUANG Yi-yi |
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| Affiliation: | (College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310032,China) |
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| Abstract: | |
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| Keywords: | procaine gastric floating sustained-release pellets |
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